News Highlight: Study on novel proton pump inhibitors

In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. Picture1These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.

Structural analysis suggests the compounds could block the ion entry pathway of the pump.

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