An exciting collaboration with the lab of Thomas Meier at Imperial College London has come to fruition, in the shape of a beautiful paper on the ATP synthase from the ‘dirty dozen’ bacterium Acinetobacter baumannii.
Check it out here, if you are interested in new ways of tackling antibiotic resistance:
We did it! After over a decade of work, we finally determined the first ‘high’ (3.2Å) resolution structure of the fungal plasma membrane proton pump, Pma1.
A heroic effort by postdoc Sabine Heit and enriched by exciting molecular dynamics simulations by DPhil student Maxwell Geurts.
Check out the paper in Science Advances here:
Excited to share the news of our newest publication:
https://pubmed.ncbi.nlm.nih.gov/32386594/
Congratulations to Sabine Heit who contributed the SERCA-CAD204520 complex crystal structure. See also her related poster here in our gallery
A great collaboration with University of Parma and CaDo Biotech, Copenhagen.
In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. 
These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.
Structural analysis suggests the compounds could block the ion entry pathway of the pump.
Check out our newest paper here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188620
Bublitz Lab 