An exciting collaboration with the lab of Thomas Meier at Imperial College London has come to fruition, in the shape of a beautiful paper on the ATP synthase from the ‘dirty dozen’ bacterium Acinetobacter baumannii.
Check it out here, if you are interested in new ways of tackling antibiotic resistance:
In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.
Structural analysis suggests the compounds could block the ion entry pathway of the pump.