An exciting collaboration with the lab of Thomas Meier at Imperial College London has come to fruition, in the shape of a beautiful paper on the ATP synthase from the ‘dirty dozen’ bacterium Acinetobacter baumannii.
Check it out here, if you are interested in new ways of tackling antibiotic resistance:
Time is flying, and as I am about to come back from maternity leave, it is time for some important updates to be mentioned. New people have started in the lab, and publications have come out – the lab is buzzing with activity! I’ll dedicate individual posts to the big news shortly!
Like labs everyhere around the world, also MBU-Lab had to move all their meetings online. Nevertheless, everyone is busy doing literature work, data analysis and structural analysis, and we’ve moved our lab meetings to Zoom.
Thanks everyone for keeping MBU-Lab running strong. Keep up the good work and – most importantly – the good spirits!
This year has been way to busy – and the MBU-Lab team has grown! It’s about time to give a proper welcome to our new lab members!
Sam Bannon has started his DPhil this fall, and Max Geurts has joined us for a 6 month rotation at the start of his Wellcome Trust Doctoral Training Programme.
Matthew Hankins has decided to do his 18-week-long 4th year ‘Part II’ project in MBU-Lab, and Katja Schlegel has enriched us with her chemistry background, vising on a 4 month ERASMUS placement from the University of Münster, Germany.
In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.
Structural analysis suggests the compounds could block the ion entry pathway of the pump.
Time flies when you’re having fun! After 12 frantic weeks, MBU-Lab’s Part II students have flown off into their well deserved Christmas break.
Have a great time with your loved ones, and fingers crossed for X-mas X-tals! It’s so quiet around here without you – looking forward to seeing you again next year!