New Publication out in Cell Chemical Biology!

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Excited to share the news of our newest publication:

Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.

Marchesini M, Gherli A, Montanaro A, Patrizi L, Sorrentino C, Pagliaro L, Rompietti C, Kitara S, Heit S, Olesen CE, Møller JV, Savi M, Bocchi L, Vilella R, Rizzi F, Baglione M, Rastelli G, Loiacono C, La Starza R, Mecucci C, Stegmaier K, Aversa F, Stilli D, Lund Winther AM, Sportoletti P, Bublitz M, Dalby-Brown W, Roti G. Cell Chem Biol. 2020 Apr 15:S2451-9456(20)30116-1. doi: 10.1016/j.chembiol.2020.04.002. Online ahead of print. PMID: 32386594

https://pubmed.ncbi.nlm.nih.gov/32386594/

Congratulations to Sabine Heit who contributed the SERCA-CAD204520 complex crystal structure. See also her related poster here in our gallery

A great collaboration with University of Parma and CaDo Biotech, Copenhagen.

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