We solved the structure of the fungal plasma membrane proton pump!

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We did it! After over a decade of work, we finally determined the first ‘high’ (3.2Å) resolution structure of the fungal plasma membrane proton pump, Pma1.

A heroic effort by postdoc Sabine Heit and enriched by exciting molecular dynamics simulations by DPhil student Maxwell Geurts.

Check out the paper in Science Advances here:

https://www.science.org/doi/10.1126/sciadv.abj5255?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
N. crassa Pma1 hexamers embedded in a model membrane. Illustration made with Blender (thanks to Anthony Cheuk, Imperial College London).

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