New Publication out in Cell Chemical Biology!


Excited to share the news of our newest publication:

Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.

Marchesini M, Gherli A, Montanaro A, Patrizi L, Sorrentino C, Pagliaro L, Rompietti C, Kitara S, Heit S, Olesen CE, Møller JV, Savi M, Bocchi L, Vilella R, Rizzi F, Baglione M, Rastelli G, Loiacono C, La Starza R, Mecucci C, Stegmaier K, Aversa F, Stilli D, Lund Winther AM, Sportoletti P, Bublitz M, Dalby-Brown W, Roti G. Cell Chem Biol. 2020 Apr 15:S2451-9456(20)30116-1. doi: 10.1016/j.chembiol.2020.04.002. Online ahead of print. PMID: 32386594

Congratulations to Sabine Heit who contributed the SERCA-CAD204520 complex crystal structure. See also her related poster here.

A great collaboration with University of Parma and CaDo Biotech, Copenhagen.

MBU-Lab goes online


These are unprecendented and difficult times.

Like labs everyhere around the world, also MBU-Lab had to move all their meetings online. Nevertheless, everyone is busy doing literature work, data analysis and structural analysis, and we’ve moved our lab meetings to Zoom.

Thanks everyone for keeping MBU-Lab running strong. Keep up the good work and – most importantly – the good spirits!