In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.
Structural analysis suggests the compounds could block the ion entry pathway of the pump.
Check out our newest paper here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188620
Sabine Heit is starting today as a postdoc in MBU-Lab. A warm welcome, we’re happy and excited that you’re joining the team!
Time flies when you’re having fun! After 12 frantic weeks, MBU-Lab’s Part II students have flown off into their well deserved Christmas break.
Have a great time with your loved ones, and fingers crossed for X-mas X-tals! It’s so quiet around here without you – looking forward to seeing you again next year!