New Publication out in Cell Chemical Biology!

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Excited to share the news of our newest publication:

Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia.

Marchesini M, Gherli A, Montanaro A, Patrizi L, Sorrentino C, Pagliaro L, Rompietti C, Kitara S, Heit S, Olesen CE, Møller JV, Savi M, Bocchi L, Vilella R, Rizzi F, Baglione M, Rastelli G, Loiacono C, La Starza R, Mecucci C, Stegmaier K, Aversa F, Stilli D, Lund Winther AM, Sportoletti P, Bublitz M, Dalby-Brown W, Roti G. Cell Chem Biol. 2020 Apr 15:S2451-9456(20)30116-1. doi: 10.1016/j.chembiol.2020.04.002. Online ahead of print. PMID: 32386594

https://pubmed.ncbi.nlm.nih.gov/32386594/

Congratulations to Sabine Heit who contributed the SERCA-CAD204520 complex crystal structure. See also her related poster here.

A great collaboration with University of Parma and CaDo Biotech, Copenhagen.

MBU-Lab goes online

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These are unprecendented and difficult times.

Like labs everyhere around the world, also MBU-Lab had to move all their meetings online. Nevertheless, everyone is busy doing literature work, data analysis and structural analysis, and we’ve moved our lab meetings to Zoom.

Thanks everyone for keeping MBU-Lab running strong. Keep up the good work and – most importantly – the good spirits!

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Welcome new lab members!

This year has been way to busy – and the MBU-Lab team has grown! It’s about time to give a proper welcome to our new lab members!

Sam Bannon has started his DPhil this fall, and Max Geurts has joined us for a 6 month rotation at the start of his Wellcome Trust Doctoral Training Programme.

Matthew Hankins has decided to do his 18-week-long 4th year ‘Part II’ project in MBU-Lab, and Katja Schlegel has enriched us with her chemistry background, vising on a 4 month ERASMUS placement from the University of Münster, Germany.

It’s great to have you on the team!

News Highlight: Study on novel proton pump inhibitors

In a new research article published in PLOS ONE, work from the Bublitz lab and the Danish company PCovery has revealed a new class of small molecule compounds, so-called tetrahydrocarbazoles, that are potent inhibitors of the fungal proton pump. Picture1These compounds can cause a breakdown of the membrane potential in fungal cells and inhibit the growth of fungi in laboratory cultures.

Structural analysis suggests the compounds could block the ion entry pathway of the pump.

Check out our newest paper here: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188620

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Merry Christmas!

Activities are slowy winding down in MBU-Lab as we approach the festive season, so I’d like to wish you all a very hapy Christmas time.

Thank you for all the hard work through this year, and I am looking forward to the exciting new science we’ll embark on in 2020!